You may have seen recent headlines or public statements suggesting a link between acetaminophen (Tylenol) use in pregnancy and autism. Understandably, this has raised questions and concerns.

At this time, there is no scientific evidence to support an association between acetaminophen use in pregnancy and autism, ADHD, or intellectual disability.

What the evidence shows

  • Acetaminophen is one of the most used medications during pregnancy to treat pain and fever.
  • In more than two decades of research, no reputable study has found that acetaminophen use in any trimester causes neurodevelopmental disorders in children.
  • The highest-quality studies to date—including one published in JAMA in 2024—showed no significant associations between acetaminophen use in pregnancy and autism, ADHD, or intellectual disability.
  • Treating conditions such as fever during pregnancy is important. Uncontrolled fever, pain, and conditions like preeclampsia can pose significant risks to both parent and baby.

What experts are saying

Both the American College of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine (SMFM) reaffirm that acetaminophen remains a safe and appropriate medication to use during pregnancy when taken as directed.

“Acetaminophen is one of the few options available to pregnant patients to treat pain and fever, which can be harmful to pregnant people when left untreated. Maternal fever, headaches as an early sign of preeclampsia, and pain are all managed with the therapeutic use of acetaminophen, making acetaminophen essential to the people who need it.” —ACOG.

What this means for you

If you are pregnant and have questions about medications, the best step is to talk directly with your WHA provider. They can help guide you on safe, effective options tailored to your individual situation.

Your health and peace of mind are important to us. We remain committed to providing accurate, evidence-based information to support you throughout your pregnancy.

Read ACOG’s statement.

Read SMFM’s response.